Posts Tagged ‘Autism Treatment’
This is the 2nd post in the “Pretty Pictures” series. To review the first post, see Pretty pictures from qEEGs and what they show.
The last article about pretty pictures that showed qEEG information of patients using biomed treatments was admittedly a teaser to whet your appetite to learn more about qEEGs as a means to validate a treatment by showing the improvements in the electrical patterns of the brain. Before I continue with this post I will reiterate what we learned in the previous post that “GREEN IS GOOD — LINES ARE BAD.” That rule will apply for all the images that follow. Also remember that the bump at the front of each head map is the nose; the two bumps on the sides are the ears and your vantage point is from above as if you are looking down on the child’s head facing forward.
Speech and language centers—receptive, expressive, and integrative–are often impaired in children on the autism spectrum. For the majority of children, speech is something that is predominantly a left brain function. Because this post is focusing on speech and the improvements that can be seen from the types of therapy we do at our clinic using our specific protocols, the next set of images I will present will highlight changes that occurred in the left side of the brain. Changes that are necessary for improved speech and language are predominantly functions of the left temporal lobe, posterior-inferior frontal lobe, and portions of the anterior-inferior parietal lobe. As you look at the picture above, the areas involved in speech and language are represented by a region that is several centimeters in size and lies adjacent to where the red (frontal lobe), green (temporal lobe), and gold (parietal lobe) come together and touch each other. Unfortunately the brain is not so simple as to just use these areas for effective speech and language. Therefore, for many children to effectively understand language and effectively speak, the brain often calls upon anatomically similar regions on the right side of the brain to help it out.
In the “BEFORE” image, you see VERY LITTLE GREEN on the left side of the brain. Instead you see yellow, orange and red brain wave activity that represents overactivity. This overactivity causes interference in the child’s ability to understand spoken language, process it appropriately, and then speak effectively. The following analogy should help you understand this concept better. If a child’s teacher is in a quiet room and asks, “Tell me what you did last night,” the child first hears the question (receptive language), processes what the teacher wants to be done (integrative language), and then tells the teacher the answer to what was asked (expressive language). However, if the radio or TV is blaring away (analogous to excess brain activity depicted as yellow, orange, or red on a QEEG), depending on how loud it is and how close the child is to the teacher will determine how much the child hears the question, can process what to do, and then give the teacher the correct answer. The reason is obvious why language did not occur at the desired moment in time, that being because there was too much activity and interference (analogous to “colors” other than green and interference “lines”).
The pictures below show young five and a half year old boy who came to our office naïve to biomedical treatments. Dr. Neubrander started him on two distinct protocols he has developed that combine methyl-B12 and soft chamber HBOT in very specific ways.
After implementing our protocols over the course of 30 days, a different pattern emerged. In the “AFTER” image, you now see A LOT OF GREEN on the left side of the brain. These green areas are the areas that correspond to the speech and language centers and demonstrate that within 30 days of intense therapy, following very specific protocols, we had made substantial”electrical improvements” in the speech and language regions of the brain. This corresponded to major “clinical improvements” documented by significant gains in language as well as cognition. Though I have not discussed it previously, the area of the brain that is responsible for executive functions–how we think and act–is located in the frontal lobes of the brain (the red area in the picture at the beginning of this post). As you compare the before and after pictures above, and additional before and after pictures of this child that will follow immediately below, not only do you see substantial improvements in the language zones, but you also see significant positive changes in both the left and right frontal areas of the brain responsible for executive functions. This is the reason that the child’s parents were amazed at how much his awareness had improved, how he was now “present” to the things going on all around him, and how he was (according to their own words), “now in our world!” As you study the before and after images below, you will see that they demonstrate quite nicely that many areas of the brain were improving, not just his speech and language centers. Though probably unnecessary, it is important to point out the obvious, that being that we cannot fix the brain in 30 days. Therefore you will see that though the “after” picture is much better than the “before” picture, we still have more work to do to “finish the job”.
Before I move on to the next case, I believe that it is important to point out that treatments need to be continued for the best results. Fortunately this boy’s family continued following Dr. Neubrander’s treatment protocols and by their 12 month follow-up, their child had continued to make significant progress and was well on his way to full or almost full recovery, something that typically requires two to three years of combined types of treatments to achieve.
In the prior blog post we showed before and after “Qs” using our MB12 protocol. You should go back and review the “Case 2: MB12 only” images now that you have a better understanding of what information the “Q” shows in relation to the improvements seen in the areas of the brain that controls our speech and language and cognitive functions. Notice the red on the left side, as well as the red in the front and on the right side is also gone and the tremendous number of red lines is also greatly reduced.
To end this post I am going to introduce a set of “Qs” using another one of our protocols, HBOT at 1.5 atmospheres of pressure. Below the “pretty pictures” I will be quoting the doctor’s notes after 30 days of treatment. Pay close attention to the left side of the brain and read the doctor’s notes below.
From the doctor’s notes:
- A severely autistic 7 year old male from a foreign country presented to me totally naïve to biomedical treatments
- He was started on methyl-B12 shots once every three days, basic antioxidants, and my 1.5 atmosphere HBOT “Diagnostic Protocol”
- My speech pathologist evaluated him at baseline and again after 30 days of therapy
- At the end of the 30 days, the parents and speech pathologist reported the following:
- Per the parents: “Mild improvements in speech and language, cognitive abilities, socialization, and emotional responses.”
- Per the speech pathologist: “From my evaluation there is an 8 month improvement in receptive language and a 16 month improvement in expressive language.”
So ends this post. I hope that you are able to see the value in how a qEEG can be used to document the progress a treatment makes in a patient. Most people do not need a “Q” to see the progress of a treatment as they can observe the patient’s positive or negative gains by the behaviors expressed. But for those who have had a “before” and “after” qEEG performed, the documentation it provides will let parents and the doctor see how effective a treatment is for the patient. In addition, if no “immediate gains” were noted, or if gains were not as strong or as intense as the parents wanted to see, the “Q” will help everyone see that the treatment is a valuable one for the child and therefore a treatment that needs to be continued long enough for the hoped-for benefits to be realized by all.
Stay tuned as next week we shall investigate the X spot in autism.
Face it, we all like pretty pictures. Nice even colors. Symmetry. No jagged lines. The beauty of a grassy hill. Well, this post is going to be all about pretty pictures.
Many parents come to me and ask, “How do I know if a treatment works? What proof do you have other than an anecdotal story?” This is where we can show them some of the information we have gathered using qEEG scans.
A qEEG is an EEG which is compared against a database of “normal” EEGs and a graph (pretty pictures) is made showing standard deviations from normal. A normal qEEG would be colored green. Those sections of the brain having too much activity would move towards red. Areas of under-activity would move towards blue. Areas of the brain that do not connect properly are graphed as lines. The thicker the line, the more severe the problem. Therefore, for this first blog all you need to know to be certified as an expert in QEEG interpretation is that GREEN IS GOOD – LINES ARE BAD!
The pictures you will see are drawn over the image of a head. As you look at each “head map”, remember that you are looking down from above. Because the pictures are so small to see clearly, note that the little bump at the top of each picture is the nose and the bumps on the sides represent the ears. As you look at the pictures, you will see that there are five rows and five columns. The meaning of each of these rows and columns is something that we will discuss in more detail in future posts. For now, all you have to know is that a “Q” is looking for several different types of abnormalities in each of these five rows and five columns. These abnormalities will be represented by colors other than green and lines that are either red or blue.
Remember that green is good and lines are bad. Therefore, the qEEG shown below is that of a fairly “normal” brain. A peaceful picture.
The next picture is a common qEEG pattern seen in children with autism. The picture is filled with ragged reds and blasé blues. It is a picture filled with many angry red and blue lines.
I will, over several blog entries, show some qEEGs in a Before and After Format. To start, I will post a before and after picture of a child doing our 6 week “trial” of MB12. The left side of the picture is the “before” image and the right is the “after” image. This “Q” is of a child using our MB12 every 3 day protocol during which absolutely no other changes were allowed other than the addition of methyl-B12. Improvements were evident in the areas of language, cognition, and socialization. Notice the reduction of the reds and the greening of the blues. Finally look at the loss of the problematic lines.
Aaahhh, we all like pretty pictures, especially pictures of success stories. In the picture that follows, you will see a before picture that demonstrates the blank stare so many children on the autism spectrum share. We call this look “Autism Eyes”. Then, for many kids, after they are treated for medical issues by the biomedical methods we use, we get a different look that we call “Autism Byes”.
Hopefully these articles will let you see that biomed is not voodoo science but has actual reproducible scientific evidence of benefit. Stay tuned. More pretty pictures to come!
This post will be my last for the present time on MB12. I will most likely return to this subject at a later date but I do not wish to lose the attention of my readers and so the next post will be on some of the other treatments we use at the clinic. But for today, I wish to focus on what Dr. Neubrander terms “A Really Cool Rat Study”.
So why would he get so excited about a study done on rats and what does it mean for the patient? Since 2002 Dr. Neubrander has been saying the MB12 given in high doses as an injection makes a difference for children with ASD. For several years it was his observations and parent anecdotes as the only confirmation that MB12 could make a difference. That all changed when this rat study came out. Now there is a bit of vindication for justifying the use of MB12 but with a slight drawback; the study did not mention autism. Through this study the benefits of MB12 on nerve and nerve repair is shown and may provide an insight into why it works on autism, but as usual, ‘more study is needed’.
I am including a comment that Dr. Neubrander gives to patients regarding the Okada study.
Please note that at the end of this comment I am including the abstract from a recent publication showing that the methyl analog from the cobalamin “family” (methyl, adenosyl, hydroxy, cyano, glutathionyl, and sulfito cobalamin) is the one that is the most biologically active. What is important to me from the article itself, not the abstract, is that though the methyl form is the most biologically active form, it is short-lived and the authors say that possibly a better delivery system is needed, e.g. “injections”. They also say that greater benefits or benefits at all are seen at the higher doses. I have been saying these exact same things for years — injections and daily shots!
Richard Deth, Ph.D. from Northeastern University in Boston, professor, colleague, and friend of mine dealing with the methylation phenomenon, is a world-renowned researcher in methionine synthase. As you know, methylcobalamin is the form of B12 that works hand-in-glove with methionine synthase. On March 31, 2010, Dr. Deth commented on the Okada article: “Although the article (Okada et al.) is basic science, it does provide some important insights into the effects of methyl-B12 (MeB12) on neurons and how it does it. Using neurons from rats, they showed that MeB12 increases the length of axons, the formation of neurites, and increases resistance to apoptosis. Together these effects indicate a significant role in development of networks among neurons. MeB12 was the best form of cobalamin for doing this, although others had activity, presumably because they were converted to MeCbl. They also showed that the effects of MeB12 reflected increased methylation, and adding SAM had similar, but weaker effects. MeB12 increased activation of the MAP kinase and PI3 kinase signaling pathways, indicating that it mimics the effects of neurotrophic growth factors. Finally, MeB12 improved the repair of transsected nerves as well as improved functional recovery of motor activity, in conjunction with increased myelination. All together a pretty impressive array of effects.“
The abstract on this study I posted below. You can look it up on pubmed, but I am listing it here for your convenience.
Exp Neurol. 2010 Apr;222(2):191-203. Epub 2010 Jan 4.
Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model.
Okada K, Tanaka H, Temporin K, Okamoto M, Kuroda Y, Moritomo H, Murase T, Yoshikawa H.
Department of Orthopaedics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Methylcobalamin is a vitamin B12 analog and is necessary for the maintenance of the nervous system. Although some previous studies have referred to the effects of methylcobalamin on neurons, the precise mechanism of this effect remains obscure. Here we show that methylcobalamin at concentrations above 100 nM promotes neurite outgrowth and neuronal survival and that these effects are mediated by the methylation cycle, a metabolic pathway involving methylation reactions. We also demonstrate that methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle. In a rat sciatic nerve injury model, continuous administration of high doses of methylcobalamin improves nerve regeneration and functional recovery. Therefore, methylcobalamin may provide the basis for better treatments of nervous disorders through effective systemic or local delivery of high doses of methylcobalamin to target organs. Copyright 2009 Elsevier Inc. All rights reserved.
PMID: 20045411 [PubMed - indexed for MEDLINE]